2018

  1. Hoffmann M, Hersch N, Merkel R, Csiszar A, Hoffmann B. J Biomed Nanotech. 2019 Jan 15 (1), 1-14.Changing the Way of Entrance: Highly Efficient Transfer of mRNA and siRNA via Fusogenic Nano-Carriers.
  2. F Büchau, C Munz, C Has, R Lehmann and TM Magin. KLHL16 degrades epidermal keratins. J Invest Dermatol; Feb 23. pii: S0022-202X(18)30140-4. . .
    doi:10.1016/j.jid.2018.02.017
  3. F Vielmuth, E Walter, M Fuchs, MY Radeva, F Buechau, TM Magin, V Spindler and J Waschke. Keratins regulate p38 MAPK dependent desmoglein binding properties in pemphigus. Front in Immunol. 2018 Mar 19;9:528 .
    doi:10.3389/fimmu.2018.00528
  4. Rietscher K, Keil R, Jordan A, Hatzfeld M. 14-3-3 proteins regulate desmosomal adhesion via plakophilins. J Cell Sci. 2018 May 22;131(10). pii: jcs212191. .
    doi:10.1242/jcs.212191
  5. M Sawant, N Schwarz, R Windoffer, TM Magin, J Krieger, N Mücke, B Obara, V Jankowski, J Jankowski, V Wally, T Lettner, J Reichelt, RE Leube. Threonine 150 phosphorylation of keratin 5 is linked to EBS and regulates filament assembly, cell cycle and oxidative stress response. J Invest Dermatol 2017 Oct 25. pii: S0022-202X(17)33079-8.
    doi:10.1016/j.jid.2017.10.011
  6. Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J, Spindler V. Keratins Regulate the Adhesive Properties of Desmosomal Cadherins through Signaling. J Invest Dermatol. 2018 Jan;138(1):121-131.
    doi:10.1016/j.jid.2017.08.033

2017

  • Hatzfeld M, Keil R, Magin TM. Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics. Cold Spring Harb Perspect Biol. 2017Jan17.pii: a029157
    doi:10.1101/cshperspect.a029157
  • Strnad P, Tacke F, Koch A, Trautwein C. (2017) Liver - guardian, modifier and target of sepsis. Nat Rev Gastroenterol Hepatol 14:55-66.
    doi:10.1038/nrgastro.2016.168
  • Mescher M, Jeong P, Knapp S, Rübsam M, Saynisch M, Kranen M, Landsberg J, Schlaak M, Mauch C, Tüting T, Niessen CM, Iden SThe epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma J Exp Med. 2017 Feb;214(2):339-358.
    doi:10.1084/jem.20160596
  • Schinner C, Vielmuth F, Rötzer, V, Hiermaier M, Radeva M, Co TK, Hartlieb E, Schmidt A, Imhof A, Messoudi A, Horn A, Schlipp A, Spindler V, Waschke J Adrenergic signaling strengthens cardiac myocyte cohesion, Circ Res.120(8):1305-1317.
    doi: 10.1161/CIRCRESAHA.116.309631
  • Ungewiß H, Vielmuth F, Suzuki ST, Maiser A, Harz H, Leonhardt H, Kugelmann D, Schlegel N, Waschke J Desmoglein 2 regulates the intestinal epithelial barrier via p38 mitogen-activated protein kinase. Sci Rep. 2017 Jul 24;7(1):6329.
    doi: 10.1038/s41598-017-06713-y
  • Nishikawa M, Naganthan S, Jülicher F, Grill S. Controlling contractile instabilities in the actomyosin cortex. . .
    doi: 10.7554/elife.19595.001
  • Daday C, Kolšek K, Gräter F. The mechano-sensing role of the unique SH3 insertion in plakin domains revealed by Molecular Dynamics simulations. Scientific Reports
    doi: 10.1038/s41598-017-11017-2
  • Rübsam M, Broussard JA, Wickström SA, Nekrasova O, Green KJ, Niessen CM. Adherens Junctions and Desmosomes Coordinate Mechanics and Signaling to Orchestrate Tissue Morphogenesis and Function: An Evolutionary Perspective. Cold Spring Harb Perspect Biol. 2017
    doi: 10.1101/cshperspect.a029207
  • Leube, R.E., M. Moch, and R. Windoffer. 2017. Intracellular Motility of Intermediate Filaments. Cold Spring Harb Perspect Biol. 9.
    doi: 10.1101/cshperspect.a021980
  • Sawant, M.S., and R.E. Leube. 2017. Consequences of Keratin Phosphorylation for Cytoskeletal Organization and Epithelial Functions. Int Rev Cell Mol Biol. 330:171-225.
  • Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horslev V, Durfresne ER, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM. E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning. Nat Commun. 2017 Nov 1
    doi: 10.1038/s41467-017-01170-7
  • M Fischer, S Uxa, C Stanko, TM Magin, K Engeland. Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway (2017). Sci Reports, Jun 1;7(1):2603.pii: a029157
    doi:10.1038/s41598-017-02831-9
  • A Volkhardt, J Bohnekamp, I Pfeiffle, C Engel, TM Magin, M Kunz. MAPK pathway inhibitors rescue lethal phenotypes in a BRAF gain-of-function Drosophila melanogaster model. Pigment Cell Melanoma Res. 2017 Dec 30.
    doi:10.1111/pcmr.12683

2016

  • Kumar V, Behr M, Kiritsi D, Scheffschick A, Grahnert A, Homberg M, Schwieger-Briel A, Bruckner-Tuderman L and TM Magin. Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease. J of Allergol and Immunol. Jun 15. pii: S0091-6749(16)30445-6.
    doi:10.1016/j.jaci.2016.04.046
  • Wallrath LL, Bohnekamp J, Magin TM. Cross talk between the cytoplasm and nucleus during development and disease. Curr Opin Genet Dev. 2016 Apr 22;37:129-136.
    doi:10.1016/j.gde.2016.03.007
  • Bohnekamp J, Cryderman DE, Thiemann DA, Magin TM, Wallrath LL. Using Drosophila for Studies of Intermediate Filaments. Methods Enzymol. 2016;568:707-26.
    doi:10.1016/bs.mie.2015.08.028
  • Hering L, Bouameur JE, Reichelt J, Magin TM, Mayer G. Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades. Elife. 2016 Feb 3;5. pii: e11117. doi
    doi:10.7554/eLife.11117
  • Keil R, Rietscher K, Hatzfeld M. Antagonistic Regulation of Intercellular Cohesion by Plakophilins 1 and 3.J Invest Dermatol. 2016Oct;136(10):2022.
    doi:10.1016/j.jid.2016.05.124
  • Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M. Growth Retardation, Loss of Desmosomal Adhesion, and Impaired Tight Junction Function Identify a Unique Role of Plakophilin 1 In Vivo. Dermatol. 2016Jul;136(7):1471-8.
    doi:10.1016/j.jid.2016.03.021
  • Ku NO, Strnad P, Bantel H, Omary MB. (2016) Keratins: Biomarkers and modulators of apoptotic and necrotic cell death in the liver. Hepatology 64:966-76.
    doi:10.1002/hep.28493
  • Strnad P, Guldiken N, Helenius TO, Misiorek JO, Nyström JH, Lähdeniemi IAK, Silvander JSG, Kuscuoglu D, Toivola DM. (2016) Simple epithelial keratins. Methods Enzymol 568:351-88.
    doi:10.1016/bs.mie.2015.08.004
  • A. Freikamp, A.L. Cost and C. Grashoff, ‘The Piconewton Force Awakens: Quantifying Mechanics in Cells’; TRENDS CELL BIOL 26(11) (2016) 838-847.
    doi:10.1016/j.tcb.2016.07.005
  • Rahn E, Thier K, Petermann P, Rübsam M, Staeheli P, Iden S, Niessen CM, Knebel-Mörsdorf, D. Epithelial barriers in murine skin during Herpes simplex virus 1 infection: the role of tight junction formation. J Invest Dermatol, 2016 Dec 6. pii: S0022-202X(16)32775-0.
    doi:10.1016/j.jid.2016.11.027
  • Ding X, Bloch W, Iden S, Rüegg MA, Hall MN, Leptin M, Partridge L, Eming SA.mTORC1 and mTORC2 regulate skin morphogenesis and epidermal barrier formation. Nat Commun. 2016 Oct 27;7:13226.
    doi:10.1038/ncomms13226.
  • Ali NJA, Dias Gomes M, Bauer R, Brodesser S, Niemann C, Iden S. Essential role of polarity protein Par3 for epidermal homeostasis through regulation of barrier function, keratinocyte differentiation and stem cell maintenance J Invest Dermatol, 2016 Jul 21. pii: S0022-202X(16)32119-4.
  • Saalbach A, Tremel J, Herbert D, Schwede K, Wandel E, Schirmer C, Anderegg U, Beck-Sickinger AG, Heiker JT, Schultz S, Magin T, Simon JC. Anti-Inflammatory Action of Keratinocyte-Derived Vaspin: Relevance for the Pathogenesis of Psoriasis. Am J Pathol. 2016 Mar;186(3):639-51.
    doi:10.1016/j.ajpath.2015.10.030

2015

  1. Tuncay H, Brinkmann B, Steinbacher T, Schürmann A, Gerke V, Iden S, and Ebnet K. JAM-A regulates cortical dynein localization through Cdc42 to control planar spindle orientation during mitosis. Nat Commun. 2015 Aug 26;6:8128
  2. Grikscheit K, Frank T, Wang Y, Grosse R. Junctional actin assembly is mediated by Formin-like 2 downstream of Rac1. J Cell Biol. 2015 May 11;209(3):367-76.
    doi:10.1083/jcb.201412015
  3. Schwarz N, Windoffer R, Magin TM, Leube RE. Dissection of keratin network formation, turnover and reorganization in living murine embryos. Sci Rep. 2015 Mar 11;5:9007. doi: 10.1038/srep09007. PMID: 25759143.
    doi:10.1038/srep09007
  4. Bhattacharya A, Schmitz U, Raatz Y, Schönherr M, Kottek T, Schauer M, Franz S, Saalbach A, Anderegg U, Wolkenhauer O, Schadendorf D, Simon JC, Magin T, Vera J, Kunz M.miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy. Oncotarget. 2015 Feb 20;6(5):2966-80. PMID: 25650662 [PubMed - indexed for MEDLINE] Free PMC Article
  5. Kant S, Holthöfer B, Magin TM, Krusche CA, Leube RE. Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function. Circ Cardiovasc Genet. 2015 Aug;8(4):553-63.
    doi:10.1161/CIRCGENETICS.114.000974.
  6. Kumar V, Bouameur J-E, Bär J, Rice RH, Hornig-Do H-T, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Wirth H, Seibel P, Magin TM. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition and activity. J Cell Biol 2015 Dec 7.
    doi:10.1083/jcb.201404147
  7. Loschke F, Homberg M, Magin TM. Keratin Isotypes Control Desmosome Stability and Dynamics through PKCα. J Invest Dermatol. 2015 Oct 12.
    doi:10.1038/jid.2015.403
  8. Bohnekamp J, Magin TM. Small molecule targeting of a myosin partner restores an intact keratin cytoskeleton despite presence of a dominant keratin mutation. Hepatology. 2015 Aug 18.
    doi:10.1002/hep.28126
  9. Homberg M, Ramms L, Schwarz N, Dreissen G, Leube RE, Merkel R, Hoffmann B, Magin TM. Distinct Impact of Two Keratin Mutations Causing Epidermolysis Bullosa Simplex on Keratinocyte Adhesion and Stiffness. J Invest Dermatol. 2015 May 11.
    doi:10.1038/jid.2015.184
  10. Bohnekamp J, Cryderman DE, Paululat A, Baccam GC, Wallrath LL, Magin TM. A Drosophila Model of Epidermolysis Bullosa Simplex. J Invest Dermatol. 2015 Apr 1.
    doi:10.1038/jid.2015.129
  11. Seltmann K, Cheng F, Wiche G, Eriksson JE, Magin TM. Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover. J Invest Dermatol. 2015 Jun;135(6):1609-20.
    doi:10.1038/jid.2015.46
  12. Loschke F, Seltmann K, Bouameur JE, Magin TM. Regulation of keratin network organization. Curr Opin Cell Biol. 2015 Feb;32:56-64.
    doi:10.1016/j.ceb.2014.12.006
  13. Spindler V, Meir M, Vigh B, Flemming S, Hütz K, Germer CT, Waschke J, Schlegel N. Loss of desmoglein2 contributes to the pathogenesis of Crohn’s disease Inflamm Bowel Dis, 21(10):2349-59..
    doi:
  14. Meir M, Flemming S, Bergauer L, Metzger M, Germer CT, Schlegel N. Glial cell line-derived neurotrophic factor (GDNF) promotes barrier maturation and wound healing in intestinal epithelial cells in vitro; AJP Gastrointestinal and Liver Physiol 2015; Oct 15;309(8):G613-24
    doi: 10.1152/ajpgi.00357.2014

2014

  1. Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, Adams IR, Magin TM, Fleischmann BK, Höhfeld J. HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell. 2014 Aug 1;25(15):2260-71. PMID: 24899640
    doi:10.1091/mbc.E14-02-0742
  2. Schönherr M, Bhattacharya A, Kottek T, Szymczak S, Köberle M, Wickenhauser C, Siebolts U, Saalbach A, Koczan D, Magin TM, Simon JC, Kunz M. Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis. Pigment Cell Melanoma Res. 2014 May;27(3):418-30. doi: 10.1111/pcmr.12216.
    doi:10.1111/pcmr.12216 PMID: 24406113
  3. Hartlieb E, Rötzer V, Radeva M, Spindler V, Waschke J. Dsg2 compensates for Dsg3 but does not control cell adhesion via regulation of p38MAPK in keratinocytes. J Biol Chem. 289(24):17043-53. (IF 2014:4.57).
    doi: 10.1074/jbc.M113.489336