Selected Publications

2018

  1. F Büchau, C Munz, C Has, R Lehmann and TM Magin. KLHL16 degrades epidermal keratins. J Invest Dermatol; Feb 23. pii: S0022-202X(18)30140-4. . .
    doi:10.1016/j.jid.2018.02.017
  2. F Vielmuth, E Walter, M Fuchs, MY Radeva, F Buechau, TM Magin, V Spindler and J Waschke. Keratins regulate p38 MAPK dependent desmoglein binding properties in pemphigus. Front in Immunol. 2018 Mar 19;9:528 .
    doi:10.3389/fimmu.2018.00528
  3. Vielmuth F, Wanuske MT, Radeva MY, Hiermaier M, Kugelmann D, Walter E, Buechau F, Magin TM, Waschke J, Spindler V. Keratins Regulate the Adhesive Properties of Desmosomal Cadherins through Signaling. J Invest Dermatol. 2018 Jan;138(1):121-131.
    doi:10.1016/j.jid.2017.08.033
  4. M Sawant, N Schwarz, R Windoffer, TM Magin, J Krieger, N Mücke, B Obara, V Jankowski, J Jankowski, V Wally, T Lettner, J Reichelt, RE Leube. Threonine 150 phosphorylation of keratin 5 is linked to EBS and regulates filament assembly, cell cycle and oxidative stress response. J Invest Dermatol 2017 Oct 25. pii: S0022-202X(17)33079-8.
    doi:10.1016/j.jid.2017.10.011

2017

  • Bouameur JE, Magin TM. Lessons from Animal Models of Cytoplasmic Intermediate Filament Proteins. Subcell Biochem. 2017;82:171-230. .
    doi:10.1007/978-3-319-49674-0_7.
  • Hatzfeld M, Keil R, Magin TM. Desmosomes and Intermediate Filaments: Their Consequences for Tissue Mechanics. Cold Spring Harb Perspect Biol. 2017Jan17.pii: a029157
    doi:10.1101/cshperspect.a029157
  • M Fischer, S Uxa, C Stanko, TM Magin, K Engeland. Human papilloma virus E7 oncoprotein abrogates the p53-p21-DREAM pathway (2017). Sci Reports, Jun 1;7(1):2603.pii: a029157
    doi:10.1038/s41598-017-02831-9
  • F Vielmuth, M Radeva, M Hiermaier, MT Wanuske, F Loschke, TM Magin, J Waschke, V Spindler. A novel function for keratins in regulating the adhesive properties of desmosomal cadherins. J Invest Dermatol. 2018 Jan;138(1):121-131
    doi:10.1016/j.jid.2017.08.033
  • A Volkhardt, J Bohnekamp, I Pfeiffle, C Engel, TM Magin, M Kunz. MAPK pathway inhibitors rescue lethal phenotypes in a BRAF gain-of-function Drosophila melanogaster model. Pigment Cell Melanoma Res. 2017 Dec 30.
    doi:10.1111/pcmr.12683

2016

  • Kumar V, Behr M, Kiritsi D, Scheffschick A, Grahnert A, Homberg M, Schwieger-Briel A, Bruckner-Tuderman L and TM Magin. Keratin-dependent TSLP expression suggests a link between skin blistering and atopic disease. J of Allergol and Immunol. Jun 15. pii: S0091-6749(16)30445-6.
    doi:10.1016/j.jaci.2016.04.046
  • Wallrath LL, Bohnekamp J, Magin TM. Cross talk between the cytoplasm and nucleus during development and disease. Curr Opin Genet Dev. 2016 Apr 22;37:129-136.
    doi:10.1016/j.gde.2016.03.007
  • Bohnekamp J, Cryderman DE, Thiemann DA, Magin TM, Wallrath LL. Using Drosophila for Studies of Intermediate Filaments. Methods Enzymol. 2016;568:707-26.
    doi:10.1016/bs.mie.2015.08.028
  • Hering L, Bouameur JE, Reichelt J, Magin TM, Mayer G. Novel origin of lamin-derived cytoplasmic intermediate filaments in tardigrades. Elife. 2016 Feb 3;5. pii: e11117. doi
    doi:10.7554/eLife.11117
  • Rietscher K, Wolf A, Hause G, Rother A, Keil R, Magin TM, Glass M, Niessen CM, Hatzfeld M. Growth retardation, loss of desmosomal adhesion and impaired tight junction function identify a unique role of plakophilin 1 in vivo. J Invest Dermatol. 2016 Mar 28. pii: S0022-202X(16)30984-8.
    doi:10.1016/j.jid.2016.03.021
  • Saalbach A, Tremel J, Herbert D, Schwede K, Wandel E, Schirmer C, Anderegg U, Beck-Sickinger AG, Heiker JT, Schultz S, Magin T, Simon JC. Anti-Inflammatory Action of Keratinocyte-Derived Vaspin: Relevance for the Pathogenesis of Psoriasis. Am J Pathol. 2016 Mar;186(3):639-51.
    doi:10.1016/j.ajpath.2015.10.030

2015

  • Kumar V, Bouameur J-E, Bär J, Rice RH, Hornig-Do H-T, Roop DR, Schwarz N, Brodesser S, Thiering S, Leube RE, Wiesner RJ, Brazel CB, Heller S, Binder H, Wirth H, Seibel P, Magin TM. A keratin scaffold regulates epidermal barrier formation, mitochondrial lipid composition and activity. J Cell Biol 2015 Dec 7.
    doi:10.1083/jcb.201404147
  • Loschke F, Homberg M, Magin TM. Keratin Isotypes Control Desmosome Stability and Dynamics through PKCα. J Invest Dermatol. 2015 Oct 12.
    doi:10.1038/jid.2015.403
  • Bohnekamp J, Magin TM. Small molecule targeting of a myosin partner restores an intact keratin cytoskeleton despite presence of a dominant keratin mutation. Hepatology. 2015 Aug 18.
    doi:10.1002/hep.28126
  • Homberg M, Ramms L, Schwarz N, Dreissen G, Leube RE, Merkel R, Hoffmann B, Magin TM. Distinct Impact of Two Keratin Mutations Causing Epidermolysis Bullosa Simplex on Keratinocyte Adhesion and Stiffness. J Invest Dermatol. 2015 May 11.
    doi:10.1038/jid.2015.184
  • Bohnekamp J, Cryderman DE, Paululat A, Baccam GC, Wallrath LL, Magin TM. A Drosophila Model of Epidermolysis Bullosa Simplex. J Invest Dermatol. 2015 Apr 1.
    doi:10.1038/jid.2015.129
  • Seltmann K, Cheng F, Wiche G, Eriksson JE, Magin TM. Keratins Stabilize Hemidesmosomes through Regulation of β4-Integrin Turnover. J Invest Dermatol. 2015 Jun;135(6):1609-20.
    doi:10.1038/jid.2015.46
  • Loschke F, Seltmann K, Bouameur JE, Magin TM. Regulation of keratin network organization. Curr Opin Cell Biol. 2015 Feb;32:56-64.
    doi:10.1016/j.ceb.2014.12.006
  • Kant S, Holthöfer B, Magin TM, Krusche CA, Leube RE. Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function. Circ Cardiovasc Genet. 2015 Aug;8(4):553-63.
    doi:10.1161/CIRCGENETICS.114.000974.
  • Schwarz N, Windoffer R, Magin TM, Leube RE. Dissection of keratin network formation, turnover and reorganization in living murine embryos. Sci Rep. 2015 Mar 11;5:9007. doi: 10.1038/srep09007. PMID: 25759143.
    doi:10.1038/srep09007
  • Bhattacharya A, Schmitz U, Raatz Y, Schönherr M, Kottek T, Schauer M, Franz S, Saalbach A, Anderegg U, Wolkenhauer O, Schadendorf D, Simon JC, Magin T, Vera J, Kunz M.miR-638 promotes melanoma metastasis and protects melanoma cells from apoptosis and autophagy. Oncotarget. 2015 Feb 20;6(5):2966-80. PMID: 25650662 [PubMed - indexed for MEDLINE] Free PMC Article
  • Rogon C, Ulbricht A, Hesse M, Alberti S, Vijayaraj P, Best D, Adams IR, Magin TM, Fleischmann BK, Höhfeld J. HSP70-binding protein HSPBP1 regulates chaperone expression at a posttranslational level and is essential for spermatogenesis. Mol Biol Cell. 2014 Aug 1;25(15):2260-71. PMID: 24899640
    doi:10.1091/mbc.E14-02-0742
  • Kant S, Holthöfer B, Magin TM, Krusche CA, Leube RE. Desmoglein 2-Dependent Arrhythmogenic Cardiomyopathy Is Caused by a Loss of Adhesive Function. Circ Cardiovasc Genet. 2015 Aug;8(4):553-63.
    doi:10.1161/CIRCGENETICS.114.000974.

2014

  • Homberg M, Magin TM. Beyond expectations: novel insights into epidermal keratin function and regulation. Int Rev Cell Mol Biol. 2014;311:265-306.
    doi:10.1016/B978-0-12-800179-0.00007-6
  • Schönherr M, Bhattacharya A, Kottek T, Szymczak S, Köberle M, Wickenhauser C, Siebolts U, Saalbach A, Koczan D, Magin TM, Simon JC, Kunz M. Genomewide RNAi screen identifies protein kinase Cb and new members of mitogen-activated protein kinase pathway as regulators of melanoma cell growth and metastasis. Pigment Cell Melanoma Res. 2014 May;27(3):418-30.
    doi:10.1111/pcmr.12216

2013

  • Seltmann K, Fritsch AW, Käs JA, Magin TM. Keratins significantly contribute to cell stiffness and impact invasive behavior. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18507-12.
    doi:10.1073/pnas.1310493110
  • Ramms L, Fabris G, Windoffer R, Schwarz N, Springer R, Zhou C, Lazar J, Stiefel S, Hersch N, Schnakenberg U, Magin TM, Leube RE, Merkel R, Hoffmann B. Keratins as the main component for the mechanical integrity of keratinocytes. Proc Natl Acad Sci U S A. 2013 Nov 12;110(46):18513-8.
    doi:10.1073/pnas.1313491110
  • Bär J, Kumar V, Roth W, Schwarz N, Richter M, Leube RE, Magin TM. Skin fragility and impaired desmosomal adhesion in mice lacking all keratins. J Invest Dermatol. 2014 Apr;134(4):1012-22.
    doi:10.1038/jid.2013.416
  • Kröger C, Loschke F, Schwarz N, Windoffer R, Leube RE, Magin TM. Keratins control intercellular adhesion involving PKC-α-mediated desmoplakin phosphorylation. J Cell Biol. 2013 May 27;201(5):681-92.
    doi:10.1083/jcb.201208162

2012

  • Roth W, Kumar V, Beer HD, Richter M, Wohlenberg C, Reuter U, Thiering S, Staratschek-Jox A, Hofmann A, Kreusch F, Schultze JL, Vogl T, Roth J, Reichelt J, Hausser I, Magin TM. Keratin 1 maintains skin integrity and participates in an inflammatory network in skin through interleukin-18. J Cell Sci. 2012 Nov 15;125(Pt 22):5269-79.
    doi:10.1242/jcs.116574
  • Roth W, Hatzfeld M, Magin TM. Targeting the palm: a leap forward toward treatment of keratin disorders. J Invest Dermatol. 2012 Jun;132(6):1541-2.
    doi:10.1038/jid.2012.99

2011

  • Windoffer R, Beil M, Magin TM, Leube RE. Cytoskeleton in motion: the dynamics of keratin intermediate filaments in epithelia. J Cell Biol. 2011 Sep 5;194(5):669-78.
    doi:10.1083/jcb.201008095
  • Kröger C, Vijayaraj P, Reuter U, Windoffer R, Simmons D, Heukamp L, Leube R, Magin TM. Placental vasculogenesis is regulated by keratin-mediated hyperoxia in murine decidual tissues. Am J Pathol. 2011 Apr;178(4):1578-90.
    doi:10.1016/j.ajpath.2010.12.055